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Title: An investigation into the effects of two bioceramics on rat mandibular bone
Author: McCord, James Fraser
ISNI:       0000 0001 3623 2979
Awarding Body: University of Edinburgh
Current Institution: University of Edinburgh
Date of Award: 1986
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The aim of this study was to evaluate the effects of both dense hydroxyapatite and ß tricalcium phosphate on mandibular bone, in an attempt to offer guidelines for their use. The importance of these guidelines is that although both of these bioceramics have been used in clinical studies there are no established guidelines to indicate which clinical situation is best served by either dense hydroxyapatite or ß tricalcium phosphate. This is evidenced by the fact that many materials have been used as dental implants and that many shapes and forms of implants have been used in an attempt either to stabilise dentures or to restore facial form. In vitro and in vivo investigations are included in this study. The in vivo investigation, on 231 male Sprague-Dawley rats contained controlled studies on weakened and unweakened mandibular bone; cryosurgery was used to weaken bone in this investigation as previous studies demonstrated significant reduction in bone strength after cryosurgery. The in vivo studies were assessed in two ways; first, mechanical assessments of fracture strengh were determined by three-point bending tests. Second, histological examination of mandibular bone was performed in parallel to the mechanical evaluation, in an attempt to interpret fracture test results from histological findings. The investigations in this thesis indicated, for the first time, that both materials result in significant increased fracture strength of mandibular bone. The histological findings indicated that these increases in fracture strength were biologically significant. The results presented in this thesis suggest that both materials are biocompatible and that g tricalcium phosphate is more ideally used in unweakened bone whereas dense hydroxyapatite, gives its optimal effect on weakened bone, although it gives more rapid early increases in strength than does g tricalcium phosphate. It is suggested that those biomaterials may be of benefit in those clinical situations where surgery on mandibular bone may render it prone to fracture.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (D.D.S.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available
Keywords: Dental implant surgery