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Title: The influence of anticoagulants on the development of colorectal cancer in the rat and their activity in human colorectal cancer
Author: Goeting, Nicola Laura Margaret
ISNI:       0000 0001 3501 5470
Awarding Body: University of Southampton
Current Institution: University of Southampton
Date of Award: 1986
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Pre-neoplastic changes were studied in an animal model for chemically induced colorectal cancer. This included cell kinetic and morphological changes, demonstrated by stathmokinetic techniques and scanning electron microscopy (SEM). The effects of warfarin [3-(a-acetonylbenzyl)-4-hydroxycoumarin] on these aspects, and tumour size and incidence were studied. These studies investigated the mechanism by which warfarin affects the development of malignancy. It was adminstered at low dose (non-therapeutic anticoagulation) and at high dose (therapeutic anticoagulation). In stathmokinetic studies the crypt cell production rate (CCPR), a cell kinetic index, was determined. The CCPR in normal animals was highest in the caecum, intermediate in descending and ascending colon, and lowest in transverse colon and rectum. With carcinogenesis CCPR increased in all areas; the greatest increase occurred in the distal colon and the smallest in the caecum. Maximum tumour yield also occurred in descending colon and rectum. Warfarin, at either dose, had no significant effect on CCPR. However tumour incidence was significantly decreased by both doses. SEM demonstrated small raised areas on the epithelial surface. Conventional histololgy demonstrated that they had adenomatous characteristics.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available
Keywords: Human anatomy & human histology