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Title: The role of the hormone relaxin in human reproduction
Author: MacLennan, Alastair Harvey
ISNI:       0000 0001 3615 7411
Awarding Body: University of Glasgow
Current Institution: University of Glasgow
Date of Award: 1985
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The polypeptide hormone relaxin has only recently been confirmed to be present in the human and specific roles for it in the human have not been delineated. The main aim of this thesis is to examine possible roles for this hormone in the human specifically in the areas of implantation of the fertilised ovum, the maintenance of myometrial quiescence during pregnancy and the facilitation of cervical ripening at parturition. As human relaxin was not available at the beginning or during any of these studies, pure porcine relaxin and a porcine relaxin radioimmunoassay were used to investigate the likely role of relaxin in the human. These studies have involved newly developed methods to purify extensive amounts of pure porcine relaxin for laboratory and clinical trials and the development of a homologous porcine relaxin radioimmunoassay for its heterologous application in measuring relaxin-like immunoactivity in the human. Where ethically and practically possible the studies were designed to investigate the role of the hormone relaxin in the human using human samples or by conducting clinical trials. However, where this was not possible, ainimal or in vitro studies have been performed to further define relaxin's possible role in reproduction.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (M.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available
Keywords: Physiology