Use this URL to cite or link to this record in EThOS: https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.371930
Title: Some theoretical aspects of drug receptor interactions
Author: Saunders, Martin
ISNI:       0000 0001 3553 975X
Awarding Body: University of Surrey
Current Institution: University of Surrey
Date of Award: 1986
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Abstract:
This thesis describes some attempts to model the effect of environment on a molecule, in particular, the effect of solvent and of the receptor site on the properties of a drug molecule. Chapter 1 describes the basic principles of drug activity, the forces responsible for binding of a drug to a receptor, and some of the consequences for drug design. Chapter 2 briefly reviews some of the quantitative structure-activity data available for angiotensin converting enzyme, and describes the design of a postulated active site by drawing an analogy with other zinc peptidases with known crystal structures. Chapter 3 briefly describes the assumptions made in the INDO semi-empirical molecular orbital method used in this study, and goes on to describe the way in which the wavefunctions obtained can be used to calculate quantities of interest to a consideration of drug-receptor interactions. The SOLVATON model for describing the effect of medium on a molecule is discussed, and some examples of its effect on small model systems are given. Finally, a method of modelling the receptor site of a drug molecule is described, and this is illustrated by its application to a model system. Chapter 4 describes the use of the INDO method in conjunction with the SOLVATON model and the receptor site modelling to obtain quantitative structure-activity relationships for a series of inhibitors of angiotensin converting enzyme. A failed attempt to model the course of reaction on a model substrate is briefly mentioned. Chapter 5 outlines some shortcomings in the methods applied, and makes suggestions for some improvements. Appendices describing the LCAO-SCF molecular orbital method, molecular mechanics and the torsion angle convention used are included, as is an appendix containing calculated indices for the compounds examined.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID: uk.bl.ethos.371930  DOI: Not available
Keywords: Pharmacology & pharmacy & pharmaceutical chemistry
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