Use this URL to cite or link to this record in EThOS: https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.370713
Title: Induction of cytochrome P-450 in in vitro hepatocyte culture systems
Author: Parker, Gerald Leslie
ISNI:       0000 0001 3470 0660
Awarding Body: University of Surrey
Current Institution: University of Surrey
Date of Award: 1985
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Abstract:
Hepatocyte isolation procedures were developed for tissue derived from Rat, Mouse, Man, Guinea pig, and Hamster. Hepatocyte cultures were derived from the above species, with the exception of Man, and successfully maintained for four days. The cultures were assessed for the ability to metabolise xenobiotics, and exposed to classical inducing agents in vitro. Induction of the cytochrome P-450 monooxygenase system was demonstrated following exposure to phenobarbitone and β-naphthoflavone, and the nature of induction characterised by use of specific enzyme substrates and inhibitors.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID: uk.bl.ethos.370713  DOI: Not available
Keywords: Genetics
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