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Title: Percutaneous penetration of penciclovir : assessment of dermal drug concentrations using cutaneous microdialysis
Author: Kay, Catherine Sunderland
ISNI:       0000 0001 3595 7791
Awarding Body: University of Southampton
Current Institution: University of Southampton
Date of Award: 2001
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The aims of this thesis were to evaluate and develop the microdialysis technique, to assess microdialysis recovery in vivo following transdermal absorption of penciclovir; to identify a topological formulation to promote penciclovir absorption with the use of penetration enhancers; to investigate the effect of blood flow of dermal levels of penciclovir following delivery with microdialysis; and to demonstrate diffusion of the drug through the dermal tissue. Cutaneous microdialysis is a technique used for the measurement of in vivo drug concentrations. Penciclovir is an antiviral drug used for the treatment of herpes labialis. In vitro skin studies showed that the penetration enhancers, oleic acid and salicyclic acid, appeared to act synergistically when applied together with penciclovir, resulting in highly significant increases in the percutaneous penetration of penciclovir (p < 0.001). An in vivo study of transdermal absorption of penciclovir with oleic acid and salicyclic acid showed that microdialysis recovery of penciclovir in the dermis was very low. In vivo microdialysis delivery of penciclovir showed that in conditions of restricted dermal blood flow, the drug accumulated in the tissue surrounding the probe and delivery was reduced (p < 0.001). With normal skin blood flow, penciclovir was cleared from the tissue, and microdialysis delivery was increased. In the same study, diffusion of the drug was assessed by a second probe. Penciclovir concentrations showed an exponential decrease with distance from the delivery probe. The concentrations recovered were higher and showed diffusion to greater distances when the dermal blood supply was restricted.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available
Keywords: Pharmacology & pharmacy & pharmaceutical chemistry