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Title: Mechanisms in the regulation of PDX1 in pancreatic β-cells
Author: McKinnon, Caroline Mary
ISNI:       0000 0001 3625 3905
Awarding Body: University of Aberdeen
Current Institution: University of Aberdeen
Date of Award: 2001
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The use of a bacterial expression system allowed the production and purification of PDX1 for in vitro phosphorylation analysis. This procedure allowed the purification of several forms of PDX1, some of which have never been reported previously. This study reiterates the fact that the activation of PDX1 and insulin gene transcription arises by a complex series of events, which are rapidly being unravelled, to provide greater insight as to how to obtain gene therapy treatments for diabetes mellitus.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available
Keywords: Insulin; Gene therapy; Diabetes mellitis