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Title: The synthesis of morphine-6-glucuronide analogues as potential analgesics
Author: Di Pretoro, Anna M. A.
ISNI:       0000 0001 3423 396X
Awarding Body: Loughborough University
Current Institution: Loughborough University
Date of Award: 1996
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It is known that morphine-6-glucuronide is more potent than morphine, but it is difficult and expensive to produce. Our aim was to synthesise an analogue(s) of morphine-6-glucuronide which would have similar or enhanced properties, but that could be obtained via a simple synthetic route. It is hoped that such a compound could be used to treat terminally ill cancer patients. Due to the enhanced potency a smaller dose of the drug would be required to effect the same analgesic effect as morphine, and this may help to reduce the effect of morphine tolerance.
Supervisor: Not available Sponsor: British Technology Group Ltd
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available
Keywords: Pharmacology & pharmacy & pharmaceutical chemistry