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Title: Synthetic studies on terpenoid lactones
Author: Toczek, Judy
ISNI:       0000 0001 3534 0871
Awarding Body: Brunel University
Current Institution: Brunel University
Date of Award: 1985
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A novel stereoselective route has been developed to a vernolepin intermediate in nine steps from 2-phenylthiocyclopentenone. During this research, a regiospecific method for the alkylation of the Δ5,6 - tetrahydroindanone system has been achieved. In addition, the synthetic route demonstrates a means of differentiating between two carboxylic acid functions via a selective lactonisation. The first total ynthesis of boonein has also been completed, in 3% yield from cyclopentadiene. This route uses a chlorine atom to direct the stereo- and regiochemical outcome of most of these reaction.
Supervisor: Lee, T. V. Sponsor: Science Research Council (SERC)
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available
Keywords: Organic chemistry