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Title: The analysis of 81Krm equilibrium inhalation data
Author: Hamilton, David
ISNI:       0000 0001 3528 3184
Awarding Body: University of Warwick
Current Institution: University of Warwick
Date of Award: 1983
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Two methods of analysing the data available from routine 81Krm equilibrium inhalation investigations were developed. The data were acquired from a gamma camera in the form of a sequential series of images from which multiple breath activity-time curves were generated for a number of regions in the lung. The first method developed was based on a description of the behaviour of the radioactive gas in the lung using a mathematical model. Values of specific mean expiratory gas flow, that is mean expiratory gas flow per unit lung volume, were calculated from the application of the model to the expiratory phase only of a single breath activity-time curve which was created from the multiple breath activity-time curve using post-acquisition gating. This method overcame the problem of the non-uniform inspiratory concentration of the tracer gas experienced in previously reported techniques of analysing inhalation data obtained using poorly soluble radioactive gases. The second method developed calculated phase differences between lung regions by cross-correlating the multiple breath activity-time curve obtained from one lung region with that obtained from another lung region. Such phase differences have not previously been measured using the inhalation of poorly soluble radioactive tracer gases.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available
Keywords: QP Physiology ; T Technology (General)