Use this URL to cite or link to this record in EThOS: https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.347264
Title: An electrophysiological study of spinal cord thermoreceptive neurones in the rat
Author: Kanui, Titus Ikusya
ISNI:       0000 0001 3594 6574
Awarding Body: University of Edinburgh
Current Institution: University of Edinburgh
Date of Award: 1983
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Abstract:
1 . The aim of this study was to investigate the neurophysiological basis for thermal analgesia. The speculation that part of this analgesia may be mediated via depression of nociceptor driven spinal cord tract neurones was tested. Spinal segments L6 to S1 were explored with extracellular mi'cropipette electrodes filled with a mixture of 5M sodium chloride and pontamine sky blue (2% in 0.5 M sodium acetate) in rats anaesthetised with chloralose (100 mg kg⁻¹) and urethane (700 mg kg⁻¹). 3. 258 neurones were recorded from within the dorsal horn and were tested for the inhibitory effect of thermal stimulation applied to the perineal, inguinal and scrotal skin. Ten of the 258 units received only a warm inhibitory input from the skin. 57 units had an excitatory input from nociceptors, of these 24 were inhibited by warming and 2 by cooling the skin. 4. Data has also teen obtained on the light microscopic anatomy of the scrotal skin and also on 73 units that had an input from thermoreceptors. 5. It is suggested that thermal inhibition of units that have an input from nociceptors may provide some neurophysiological basis for thermal analgesia.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID: uk.bl.ethos.347264  DOI: Not available
Keywords: Human anatomy & human histology
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