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Title: Monoamine-sensitive adenylate cyclase in the nervous system of the locust Schistocerca gregaria
Author: Kilpatrick, Andrew Thomas
ISNI:       0000 0001 3599 2167
Awarding Body: University of Glasgow
Current Institution: University of Glasgow
Date of Award: 1981
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The observation that dopamine, octopamine and serotonin represent the major monoamines present in insect nervous tissue has led to speculation about their role. For the monoamines to act as neurotransmitters, receptors should exist. Moreover, if chemical neurotransmission involves cyclic AMP as a "second messenger", then monoamine receptors linked to adenylate cyclase should also be present. The aim of this work was to determine whether locust cerebral ganglia possessed an adenylate cyclase that was affected by these monoamines present in Schistocerca gregaria nervous tissue and, if so, to see if the response was mediated by separate receptors. In addition, a comparison of the properties of the locust adenylate cyclase with those from other organisms was carried out. Cerebral ganglia of S. gregaria contain an adenylate cyclase-4 stimulated maximally, in the presence of 10.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available
Keywords: Biochemistry