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Title: Stability studies on penicillin derivatives
Author: Hempenstall, John M.
ISNI:       0000 0001 3552 5219
Awarding Body: University of Aston in Birmingham
Current Institution: Aston University
Date of Award: 1982
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Current analytical assay methods for ampicillin sodium and cloxacillin sodium are discussed and compared, High Performance Liquid Chromatography (H.P.L.C.) being chosen as the most accurate, specific and precise. New H.P.L.C. methods for the analysis of benzathine cloxacillin~ benzathine penicillin V; procaine penicillin injection B.P.; benethamine penicillin injection; fortified B.P.C.; benzathine penicillin injection; benzathine penicillin injection, fortified B.P.C.; benzath ine penicillin susp2nsion; ampicillin syrups and penicillin syrups are described. Mechanical or chen ical damage to COlUITU1 packings is often associated with H.P.L.C. analysis. One type, that of channel formation, is investigated. The high linear velocity of solvent and solvent pulsing during the pumping cycle were found to be the cause of this damage. The applicability of nonisotherrnal kinetic experiments to penicillin V prep3.rations, including formulated p3.ediatric syrufS, is evaluated. A new tyt::e of nonisotherrnal analysis, based on slope estimation and using a "4K Random Access Memory (R..A.M.) microcanputer is described. The name of the program written for this analysis is NJNISO. The distribution of active penicillin in granules for reconstitution into ampicillin and penicillin V syrups, and its effect on the stability of the reconstituted products, are investigated. Changing the dil uent used to reconsti tue the syrups was found to affect the stability of the product. Dissolution and stability of benzathine cloxacillin at pH2, pH6 and pH9 is described, wi th proposed dissolution mechanisms and kinetic analysis to suppJrt these mechanisms. Benzathine and cloxacillin were found to react in solution at pH9, producing an insoluble amide.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available
Keywords: Pharmacology & pharmacy & pharmaceutical chemistry