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Title: Growth in utero, blood pressure and elasticity of the aorta and large conduit arteries
Author: Phillips, Nirree Jane
ISNI:       0000 0001 3489 2017
Awarding Body: University of Southampton
Current Institution: University of Southampton
Date of Award: 2000
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The work in this thesis investigates the idea that diminished elastin synthesis during fetal and early postnatal life leads to modifications in arterial structure resulting in a reduction in the elastic properties of the arteries and a rise in blood pressure. The work falls into two parts. The first concerns epidemiological studies in humans. The aim was to examine relationships between indicators of poor fetal growth and arterial compliance in three groups: elderly men and women, young adults and children. Detail birth records were available for all. Arterial compliance was estimated by measuring pulse wave velocity. The technique depends on the principle that the speed at which pulse waves travel through a liquid filled tube is inversely proportional to the square root of the compliance of the tube's wall. The results of the studies in humans showed that people who were born with indicators of fetal growth restriction in mid to late pregnancy tended to have faster pulse wave velocities in the aorta to femoral, aorta to radical and aorta to foot arterial segments. Although the actual birth measurements that were related to pulse wave velocity were not the same across the studies, the likely timing of the growth restricting factors was consistent. For example, in elderly men and women, for each unit decrease in ponderal index (oz/in³ x 1000), aorta to femoral pulse wave velocity increased by 16% (p=0.05). In elderly men and women, for each gram increase in placental weight, aorta to radial pulse wave velocity increased by 0.033 m/sec (p=0.02). For each day decrease in gestational age, aorta to foot pulse wave velocity increased by 0.5% (p=0.01) in young adults and by 0.013 m/sec (p=0.04) in children. The second part of this thesis concerns experiments on animals.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available
Keywords: Fetal; High; low birth weight