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Title: A synthetic approach to antiprogestational steroids
Author: Ayerman, Farah
ISNI:       0000 0001 3433 8542
Awarding Body: City, University of London
Current Institution: City, University of London
Date of Award: 1996
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The nature and uses of some steroidal hormones and anti-hormones are reviewed, with an emphasis on the anti-progestins which have anti-implantation activity. A new type of steroid structure has been designed which combines two types of structural elements, namely an A-nor skeleton and an 11-aryl substituent, which are separately known to display anti-implantation properties. It is demonstrated that a thallium-mediated ring contraction of steroidal 4-en-3-ones carrying an 11-keto group provides entry to a functionalised A-nor steroid skeleton which can then be arylated using organolithium reagents. Manipulation of the functionalities led to the successful synthesis of ll-phenyl-A-nor-5ft-androst-2,17- dione, which should be a valuable intermediate for the generation of a set of 11-arylated A-nor steroids for biological evaluation.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available
Keywords: QD Chemistry