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Title: Biophysics and biochemistry of the pancreatic β-cell
Author: Kelly, Ronan
Awarding Body: University of Oxford
Current Institution: University of Oxford
Date of Award: 1989
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The β-cells of the pancreatic islets of Langerhans are the endocrine cells which secrete the hypoglycaemic hormone insulin. The primary stimulus for insulin secretion is an increase in the plasma glucose concentration, although secretion can be modulated by a variety of hormones and neurotransmitters. The immediate signal for insulin release is calcium entry through the β-cell plasma membrane. Primary secretagogues are glucose and those other secretagogues capable of initiating insulin secretion (e.g. glyceraldehyde, leucine, 2- ketoisokaproate); secondary secretagogues are those which potentiate the effect of glucose but which cannot initiate insulin secretion in the absence of glucose (glucagon, ACh, Forskolin, phorbol esters). Both glucose and the various agents which modulate insulin secretion do so by altering the pattern of B-cell electrical activity, and hence Ca2+ influx. This thesis examines the ionic basis of B-cell electrical activity and the mechanism of its initiation by glucose.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available
Keywords: Biochemistry