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Title: Novel enantiopure ligands for asymmetric catalysis
Author: Frost, Christopher Gregory
ISNI:       0000 0001 3484 7195
Awarding Body: Loughborough University of Technology
Current Institution: Loughborough University
Date of Award: 1994
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The scope of the palladium catalysed allylic substitution reaction is reviewed with particular reference to stereocontrol. The use of enantiopure oxazolines and acetals in asymmetric synthesis is briefly outlined. The work presented is concerned with the design and construction of enantiopure ligands which are able to impart very high levels of enantioselectivity in the aforementioned palladium-catalysed allylic substitution reaction. The ligands exploit the stereochemistry-controlling properties of the oxazoline moiety, whilst incorporating a secondary donor atom. The ligands rely upon an electronic disparity between these two atoms to direct nucleophilic addition.
Supervisor: Not available Sponsor: Science and Engineering Research Council
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available
Keywords: Transition metal based catalysts; Organometallics