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Title: On the population structure of Mycobacterium tuberculosis
Author: Olson, Ewan Sinclair
ISNI:       0000 0001 3458 5527
Awarding Body: University of Glasgow
Current Institution: University of Glasgow
Date of Award: 1997
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The thesis is based on the results of analysis of a collection of Scottish isolates by pulsed- field gel electrophoresis and also by IS6110 Southern blotting. It also contains a review of the literature on Mycobacterium tuberculosis complex with an emphasis on strain typing and of the literature on population structures of bacteria. Based on the results and the literature review the following conclusions are drawn: 1. The population structure of Scottish isolates of the species Mycobacterium tuberculosis is clonal. 2. The genetic diversity of the Scottish isolates is so limited that the population structure forms a single clone. 3. Evidence is presented that the clone is not confined to Scotland and that all members of the species may be part of a single clone. 4. The work presented supports the hypothesis that the species Mycobacterium bovis is not a distinct species but a biovar of Mycobacterium tuberculosis.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (M.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available
Keywords: Medicine