The findings embodied in this thesis have been discussed in the following two sections. A. Comparative Serology The indirect fluorescent antibody test (IFA) and the enzyme-linked immunosorbent assay test (ELISA) have been investigated for their sensitivity in determining IgG antibody levels in human sera to Herpes simplex virus type 1, Coxsackievirus and Rotavirus, The results obtained have been correlated with those obtained from neutralisation or complement fixation tests in an attempt to evaluate the relevance of the antibodies detected by these serological procedures. B. Virus Antibody Profiling A novel technique for discriminating between human bloodstains has been developed and the suitability of the IFA and ELISA tests for use in this procedure has been investigated.