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Title: Studies on neural regulation of blood pressure in hypertension
Author: Floras, John Stanley
ISNI:       0000 0001 3470 8400
Awarding Body: University of Oxford
Current Institution: University of Oxford
Date of Award: 1981
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Resetting of baroreceptor afferent firing in hypertensive animals, and the reduction in baroreflex regulation of the heart rate seen in man, are thought to be secondary to changes in vascular distensibility in hypertension. Diminished baroreflex sensitivity should be reflected in a withdrawal of inhibition of sympathetic nervous function. This hypothesis was investigated in 62 hypertensive subjects using three indirect indices of sympathetic nervous activity: (1) the haemodynamic responses to mental and physical exercise, (2) plasma noradrenaline concentrations at rest, and on exercise, and (3) the beat-to-beat variability of waking ambulatory blood pressure. Subjects with diminished baroreflex sensitivity (1) achieved higher maximum mean arterial blood pressures during four different exercises, and greater absolute increases in blood pressure when bicycling, (2) tended (P
Supervisor: Jones, John Vann Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available
Keywords: Blood pressure ; Regulation ; Hypertension ; Baroreflexes