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Title: Characterisation and use of radiotracers in studies of inflammatory tissue and opioid binding sites
Author: Lawrence, Andrew John
ISNI:       0000 0001 3605 907X
Awarding Body: Loughborough University of Technology
Current Institution: Loughborough University
Date of Award: 1990
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The thesis is presented in two parts, part one concerns the synthesis and biodistribution of technetium–porphyrin complexes. A series of compounds with the general formula TcO(Porhyrin)OAc and TcO(Phthalocyanine)OPh have been synthesised via a novel route. The starting material comprised NH4TcO4 with acetic acid for the porphyrin and phenol for the phthalocyanine. The compounds have been characterised both qualitatively and quantitatively by infra-red, ultra-violet and mass spectrometry. Thin Layer Chromatography (TLC) and electrophoresis have also been employed to further analyse the complexes. Preliminary biodistribution studies have been performed in a model of inflamed tissue. The results suggest that the labelled porphyrins are capable of imaging such tissue. One of the complexes was tested for an ability to accumulate in, and image tumours, however this proved unsuccessful.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available
Keywords: Technetium-porphyrin complexes