Use this URL to cite or link to this record in EThOS: https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.251674
Title: Practical considerations in designing and analysing cross-over clinical trials
Author: Lambrou, Dimitrios Nikolaos
ISNI:       0000 0001 3604 4257
Awarding Body: University of London
Current Institution: University College London (University of London)
Date of Award: 2001
Availability of Full Text:
Access from EThOS:
Full text unavailable from EThOS. Please try the link below.
Access from Institution:
Abstract:
The problem of carry-over in cross-over trials has driven research activity for many decades. Depending on the assumptions made concerning carry-over effect in the 2×2 design, the CROS or the PAR estimator is selected for estimating treatment effect. The two stage procedure, selecting CROS with probability p and PAR with probability 1-p, achieves lower power and higher type I error-rate when compared to CROS. A corrected scheme, which achieves the nominal type I error-rate, proves inferior to alternative schemes regarding power and Mean Square Error Estimation rate. When baseline measurements are included in the analysis of the 2×2 design, a three-stage procedure emerges with similar properties to the two-stage one. The optimum plan for designing a cross-over study in families with more than two periods and/or sequences, depends on the assumptions made for the carry-over effects and the optimality criterion chosen. Best plans for two treatments, when model mis-specification occurs in both the systematic and/or random part of the model assumed to have generated the observed data, are derived. When three or more treatments are compared, optimum cyclic plans are chosen under a wide range of assumptions concerning carry-over activity.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID: uk.bl.ethos.251674  DOI: Not available
Keywords: Medicine
Share: