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Title: Lewis acid mediated reactions of olefins with carbonyls
Author: Flower, Stephen
Awarding Body: University of Bath
Current Institution: University of Bath
Date of Award: 2002
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This thesis is divided into 5 chapters. The first chapter reviews the literature of Carbonyl-ene and Prins reactions. Recent advances in these areas and their application to natural product synthesis and other targeted syntheses are discussed. The second chapter discusses the concept of desymmetrisation using selected examples, including desymmetrising Carbonyl-ene reactions. Chapter Three introduces and discusses the work undertaken in studying the desymmetrising intramolecular carbonyl-ene of a meso-dialdehyde. Chapter Four details the concept of pyruvate-Prins cyclisation giving examples of its potential use. The chapter also gives examples of the use of rigid stereodefined scaffolds and their application. The chapter describes the reactivity of substituted pyruvate esters with cyclic enol ethers, and the elaboration of the cyclised products. The fifth chapter provides experimental details of the procedures reported.
Supervisor: Willis, Michael Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available
Keywords: Carbonylene reactions