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Title: The synthesis and pharmacological evaluation of quisqualic acid and some novel excitatory amino acid mimetics
Author: Okonkwo, P. I.
ISNI:       0000 0001 3455 9468
Awarding Body: London Guildhall University
Current Institution: London Metropolitan University
Date of Award: 1992
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L-Glutamic acid and L-aspartic acid are believed to be the principal initiators of excitatory synaptic neurotransmission in the mammalian central system. A number of molecules of either natural or synthetic origin have been identified as possessing agonist or antagonist properties at glutamate binding sites. One of the most potent agonist is quisqualic acid (69), and this thesis features two aspects of the synthetic organic chemistry and the pharmacology of quisqualic acid and some of its analogues.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available
Keywords: 500 Natural Sciences and Mathematics ; 540 Chemistry & allied sciences