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Title: Towards the synthesis of fluoro-thromboxane A₂ analogues
Author: Collier, Ian D.
ISNI:       0000 0001 3560 4398
Awarding Body: University of Stirling
Current Institution: University of Stirling
Date of Award: 1988
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Firstly, the biosynthesis and physiological role of thromboxanes and the potential for a thromboxane A2 antagonist in cardiovascular therapy are discussed. Secondly, the importance of fluorine in drug design is outlined and the syntheses of a series of thromboxane A2 structural analogues are reviewed. This is concluded by proposing how fluorine substitution should allow synthesis of a stable structural analogue of thromboxane A2 which may have antagonistic properties. Finally, the synthetic conversion of a carbohydrate precursor, levoglucosan, into a suitable precursor to 10-α-flurothromboxane A2 is discussed in detail.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available
Keywords: Thromboxanes--Analysis ; Eicosanoids ; Prostanoids