Use this URL to cite or link to this record in EThOS: http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.731204
Title: Time-delayed models of genetic regulatory networks
Author: Parmar, Kiresh
ISNI:       0000 0004 6494 9418
Awarding Body: University of Sussex
Current Institution: University of Sussex
Date of Award: 2017
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Abstract:
In this thesis I have analysed several mathematical models, which represent the dynamics of genetic regulatory networks. Methods of bifurcation analysis and direct numerical simulations were employed to study the biological phenomena that can occur due to the presence of time delays, such as stable periodic oscillations induced by Hopf bifurcations. To highlight the biological implications of time-delayed systems, different models of genetic regulatory networks as relevant to the onset and development of cancer were studied in detail, as well as genetic regulatory networks which describe the effects of transcription factors in the immune system. A network of an oscillator coupled with a switch was explored, as systems such as these are prevalent in genetic regulatory networks. The effects of time delays on its oscillatory and bistable behaviour were then investigated, the results of which were compared with available results from the literature.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID: uk.bl.ethos.731204  DOI: Not available
Keywords: QH0438.4.M3 Mathematical models
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