Use this URL to cite or link to this record in EThOS: http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.728942
Title: Studies into iridium-catalysed asymmetric allylic alkylation towards the total synthesis of a dolabellane
Author: Jiang, Lingfan
Awarding Body: University of Oxford
Current Institution: University of Oxford
Date of Award: 2016
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Abstract:
In recent years, iridium-catalysed asymmetric allylic substitution has received considerable attention because it is a valuable tool to selectively synthesise chiral compounds with high ee from simple starting materials. This thesis presents an efficient catalytic system for the decarboxylative iridium-catalysed asymmetric allylic alkylation (AAA) in which a wide range of allylic β-ketoester substrates was converted into chiral ketones in good yields with high regio- and enantioselectivities. A possible mechanism for decarboxylative iridium-catalysed AAA is also proposed in this thesis.
Supervisor: Burton, Jonathan Sponsor: Agency for Science Technology and Research
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID: uk.bl.ethos.728942  DOI: Not available
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