Use this URL to cite or link to this record in EThOS: http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.716434
Title: Studies towards a total synthesis of tagetitoxin
Author: Mahoney, Brian
Awarding Body: University of East Anglia
Current Institution: University of East Anglia
Date of Award: 2017
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Abstract:
Tagetitoxin was first isolated over thirty five years ago and a total synthesis has not been achieved to date. A vast amount of research has been carried out on the biological activity of tagetitoxin with hundreds of literature reports. However, very few papers have been published regarding the synthesis and within this thesis we will explore a number of synthetic pathways some towards tagetitoxin. The first chapter reviews previous developments regarding the total synthesis of tagetitoxin. It also covers the discovery and biological work that has being carried out in identifying the structure and the biological activity of tagetitoxin. The second part reports my studies towards a total synthesis of tagetitoxin. It details all the routes explored showing the key intermediates and novel compounds we obtained. The third and final part contains the experimental data for all compounds discussed in part two of this thesis.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID: uk.bl.ethos.716434  DOI: Not available
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