Use this URL to cite or link to this record in EThOS: http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.714971
Title: Investigating the evolutionary origins and cell biology of Negativicutes
Author: Brown, Richard Francis
Awarding Body: University of Warwick
Current Institution: University of Warwick
Date of Award: 2016
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Abstract:
The Negativicutes are a class of bacteria within the predominantly Grampositive phylum Firmicutes that possess a diderm Gram-negative cell envelope along with lipopolysaccharides. Remarkably, some members of this class of Gram-negative bacteria can form endospores. The evolutionary origins of this enigmatic class were investigated through bioinformatics analyses, which defined and characterised their Gram-negative and Gram-positive toolkits, while analyses of Gram-negative signature proteins provided insights into the origins of the Gram-negative toolkit. The genome of Sporomusa sphaeroides, a sporulating species from the Negativicutes, was sequenced and annotated for the first time. In addition, the transcriptional landscapes of Veillonella parvula and Sporomusa sphaeroides during logarithmic and stationary phase growth were investigated using RNA-Seq, expanding the repertoire of known genome features, including non-coding RNAs within these species.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID: uk.bl.ethos.714971  DOI: Not available
Keywords: QH Natural history
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