Use this URL to cite or link to this record in EThOS: http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.714495
Title: Strategies to enhance the bioactive nature of peek polymer surfaces using calcium phosphate coatings
Author: Robinson, Leanne
Awarding Body: Ulster University
Current Institution: Ulster University
Date of Award: 2017
Availability of Full Text:
Full text unavailable from EThOS. Thesis embargoed until 01 Apr 2019
Abstract:
This research investigated the potential to deliver substituted CaP thin films onto medically relevant substrates, in a one step process, via RFMS, so as to enhance the substrates surface topography and chemistry to stimulate an enhanced osteoblastic response. RFMS was utilised initially to sputter deposit (substituted-Sr and/ Zn) CaP onto Ti. Chemical and topographical surface properties in both the as-deposited and annealed state at 500 °C were investigated. Studies were undertaken which placed special emphasis on how the chemistry and morphology of (substituted) CaP coatings, sputter deposited onto PEEK, altered in relation to the deposition parameters. It was realised that a gradient interlayer was created between the PEEK substrate and the (substituted) CaP coating due to the calcium, phosphate and substituted ions being implanted within the PEEK to different depths in an erosion/ deposition process and that all of the coatings produced were amorphous, this created chemical and morphological changes to the PEEK substrate, but no damage to the bulk material. With the addition of impurity ion(s) the thin film formation took longer indicating a slower development rate. The chemical and morphological stability of the various (substituted) CaP coatings deposited onto PEEK were studied under physiological conditions, each coating had the ability to withstand this environment for 14 days. The in vitro response to the neat PEEK and (substituted) CaP surfaces was investigated up to 21 days, with all sample types proving their capability in supporting early cell attachment and proliferation. ALP measurements indicated high levels of initial differential potential on the Sr substituted CaP modified PEEK and the crystalline (substituted) CaP modified Si. By day 14 the (substituted) CaP modified PEEK samples maintained the highest levels of osteogenic differentiation. The Sr substituted CaP modified PEEK substrates promoted earlier and prolonged differentiation potential when compared to the CaP coated PEEK.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID: uk.bl.ethos.714495  DOI: Not available
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