Use this URL to cite or link to this record in EThOS: http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.704871
Title: Regulation of medullary homeostasis by thymic epithelial cells
Author: McCarthy, Nicholas Ian
ISNI:       0000 0004 6057 564X
Awarding Body: University of Birmingham
Current Institution: University of Birmingham
Date of Award: 2017
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Abstract:
The development of αβ T-cells is a step-wise process guided by unique stromal microenvironments within the thymus, which results in the formation of T-cells with a highly diverse repertoire of T-cell receptors (TCRs). In the latter stages of development, T-cell tolerance is established through the selective deletion of cells expressing auto-reactive TCRs, in addition to the generation of immunosuppressive regulatory T-cells (T-Reg). Central tolerance induction is mediated by interaction with functionality heterogeneous medullary thymic epithelial cells (mTEC). The aim of this study was to search for a novel mTEC-expressed functional molecules involved in medullary homeostasis and central tolerance. Here we identify two novel mTEC populations; cells expressing osteoprotegerin (OPG), a negative regulator of Rank-mediated mTEC maturation, and inducible nitric oxide synthase (iNOS), an immune-active enzyme catalysing the production of nitric oxide. Importantly, we found OPG to restrict the size of the mTEC compartment, which in contrast to previous findings had no impact on T-Reg production, and instead limited the influx of peripheral lymphocytes to the thymus. In contrast, iNOS appears to play only a minor role in the maturation of single positive thymocytes in the medulla. These findings highlight the importance of functionally distinct mTEC compartments in maintaining medullary homeostasis.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID: uk.bl.ethos.704871  DOI: Not available
Keywords: QR180 Immunology ; RC Internal medicine
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