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Title: Developing nucleophilic nitrenoids for the synthesis of complex heterocycles
Author: Garzon Sanz, Miguel
ISNI:       0000 0004 5994 6538
Awarding Body: University of Birmingham
Current Institution: University of Birmingham
Date of Award: 2016
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The combination of nucleophilic nitrenoids and gold-catalysis has rapidly emerged as a powerful tool in the assembling of different nitrogen-containing motifs. The research presented in this thesis describes the advances in the field and the exploration of pyrimidium \(N\)-heteroaryl aminides as building blocks in the formation of several fused imidazoheterocycles. From the initial discovery of this reaction and its application in the synthesis of imidazo[1,2-a]pyrimidines, the scope of this convergent gold-catalysed strategy has been adapted to allow the access to fourteen classes of biologically relevant structures. The proposed mechanism and optimisation will be discussed alongside the accommodation of a wide range of useful functionalities difficult to introduce by other methodologies.
Supervisor: Not available Sponsor: University of Birmingham
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available
Keywords: QD Chemistry