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Title: The synthesis of biologically active guanidines
Author: Harper, Philip Mark
ISNI:       0000 0004 5993 4828
Awarding Body: Prifysgol Bangor University
Current Institution: Bangor University
Date of Award: 2016
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Several new alkyl (147, 161 and 167) and alkoxy-methyl derivatives (171, 175) were prepared as analogues of the anti-tumour agent tirapazamine (38). These were prepared in an attempt to couple them to the pro-drug delivery agent 52. The bicyclic guanidine natural product monalidine A (186) was prepared as its hydrochloride salt from 2-undecanone via a novel 3-step synthesis. The biological activity of monalidine A (186) and one of its synthetic precursors were evaluated against Leishmaniasis infantum and Trypanosoma cruzi. Research towards the total synthesis of the tricyclic arbusculidine A (187) from cucumber aldehyde is reported.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available