Use this URL to cite or link to this record in EThOS: http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.698913
Title: Synthesis of uracil containing precursors and analogues of cylindrospermopsin
Author: Fituri, Hisham Saleh
ISNI:       0000 0004 5993 4094
Awarding Body: Prifysgol Bangor University
Current Institution: Bangor University
Date of Award: 2015
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Abstract:
The thesis covers three topics: i) Synthesis of the uracil D-ring precursor of the cylindrospermopsin alkaloids: this study entailed the preparation of compounds I and II which were shown to be a RHS D-ring precursor in the synthesis of the cylindrospermopsin alkaloids. Compound I was prepared in 3 steps and in 24% overall yield from dibenzylurea whilst II was prepared from either diethyl 1,3-acetonedicarboxylate in 5 steps and 9% overall yield or barbituric acid in 5 steps and 16% overall yield. ii) Preparation of analogues of cylindrospermopsin: the synthesis of the cylindrospermopsin analogue III was achieved in 6 steps and 12% overall yield from the literature compound 2,6-dimethoxypyrimidine-4-carboxaldehyde. iii) Preparation and enzymatic studies on 2.4-dinitrobenzamide pro-drugs: the known pro-drugs IV (X = Cl, Br, I), were prepared and found to be good substrates for the enzyme NfsA NTR. These can thus be considered as alternative pro-drugs to the usually employed CB 1954 in combination with NfsA NTR for human chemotherapy.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID: uk.bl.ethos.698913  DOI: Not available
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