Use this URL to cite or link to this record in EThOS:
Title: Synthesis of aminosterols structurally related to squalamine
Author: Matthews, Andrew John
Awarding Body: University of Leicester
Current Institution: University of Leicester
Date of Award: 2001
Availability of Full Text:
Access from EThOS:
Access from Institution:
Squalamine is a naturally occurring broad-spectrum antimicrobial agent isolated from the dogfish shark Squalus acanthias. It has been shown to have biological activity against both Gram-negative and Gram-positive bacteria, fungi, sexually transmitted diseases (STDs) and cancer. A flexible synthetic route to polyamine-steroid conjugates structurally related to squalamine has been developed. Five different steroids and have been prepared, three of which have been combined with the protected polyamines shown below to give a large combinatorial library of aminosterols. (Fig. 8782A). Reductive amination was used to combine the steroids with the protected polyamines, and putrescine. (Fig. 8782B). Forty-four aminosterols were synthesised and are currently being tested for antimicrobial and anticancer activity.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available