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Title: Event-related potentials in obsessive-compulsive disorder
Author: Rogers, Dave Edward
ISNI:       0000 0004 5992 6991
Awarding Body: Queen's University Belfast
Current Institution: Queen's University Belfast
Date of Award: 2015
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A meta-analysis of event-related potential (ERP) studies between controls and high-OCD groups was conducted to examine whether there is a consistent relationship between differences in P300 amplitude and latency following exposure to OCD-related stimuli.After applying exclusion and inclusion criteria, 10 studies remained. The overall effect size for amplitudinal P300 differences was non-significant and results were heterogeneous, while the overall findings for latency were significant. There is therefore tentative evidence from this meta-analysis that reduced P300 latency is a neural correlate for late onset attentional bias in OCD. In the large scale study, a control group of low OCS participants ,was compared to nonclinical high OCS participants on dependent variables of event-related potential amplitude and response time. EEG differences in P100 and ipsilateral invalid negativity (IIN) were investigated as neural correlates of the facilitated attention and disengagement biases respectively. Significant differences were found between groups across IIN amplitude only, suggesting effortful disengagement only occurred in the high OCD groups under selected conditions. The implication is that delayed disengagement is the main attentional bias associated with OCD symptomatology.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (D.Clin.Psych.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available