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Title: Long term outcomes in kidney transplantation
Author: McCaughan, Jennifer A.
ISNI:       0000 0004 5990 6448
Awarding Body: Queen's University Belfast
Current Institution: Queen's University Belfast
Date of Award: 2015
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Kidney transplantation is a life transforming procedure which substantially improves the quality and quantity of life of individuals with end stage renal disease. The short term outcomes following kidney transplantation are now excellent but recipients continue to experience significant long term morbidity. This thesis investigates the clinical, genetic and epigenetic factors which influence long term graft and recipient outcomes after kidney transplantation with a particular focus on the major, life limiting complications. Chapter 3 investigates the impact of DNA methylation and single nucleotide polymorphisms in a candidate gene on death censored graft survival. In addition, the possibility of anticipating death censored graft survival from a recipients clinical course is explored. In Chapter 4, DNA methylation signatures associated with recipient survival and cardiovascular disease are investigated long with the genetic basis of new onset diabetes after transplantation and the national incidence of non melanoma skin cancer. Chapter 5 focuses on topical issues in kidney transplantation; the impact of obesity on graft and recipient outcomes and of graft failure on recipient survival are studied. Finally I the characteristics and clinical course of recipients with ultra long term graft survival are described in Chapter 6.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available