Use this URL to cite or link to this record in EThOS: http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.695407
Title: Studies towards the asymmetric synthesis of mechanically planar chiral rotaxanes
Author: Glen, Pauline Elizabeth
Awarding Body: Heriot-Watt University
Current Institution: Heriot-Watt University
Date of Award: 2013
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Abstract:
The work reported in this thesis consists of studies towards the asymmetric synthesis of mechanically planar chiral rotaxanes via an asymmetric active template approach. It describes the synthesis of a novel C1-symmetric bis(oxazoline) macrocycle and the investigation of this C1-symmetric bis(oxazoline) macrocycle, and other C1- and C2- symmetric non-macrocyclic bis(oxazoline)s, as ligands in the Cadiot-Chodkiewicz, oxidative Heck and CuAAC ‘click’ reactions as part of the study towards the synthesis of asymmetric planar chiral rotaxanes. The thesis is divided into four chapters: Chapter one is an introduction to rotaxanes and includes an overview of the synthesis of rotaxanes and chirality in rotaxanes. Chapter two is an account of the synthesis of a novel C1-symmetric bis(oxazoline) macrocycle. Chapter three describes the investigation of bis(oxazoline)s, C1- and C2-symmetric, macrocyclic and non-macrocyclic, as ligands in the Cadiot-Chodkiewicz, oxidative Heck and CuAAC ‘click’ reaction. Chapter four provides a formal report of the experimental procedures.
Supervisor: Not available Sponsor: EPSRC
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID: uk.bl.ethos.695407  DOI: Not available
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