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Title: Benchmarking and control of bovine viral diarrhoea (BVD) in dairy and suckler herds in Northern Ireland
Author: Guelbenzu Gonzalo, Maria del Pilar
ISNI:       0000 0004 5988 8788
Awarding Body: Queen's University Belfast
Current Institution: Queen's University Belfast
Date of Award: 2015
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Bovine viral diarrhoea (BVD) is a highly significant endemic disease of cattle caused by bovine viral diarrhoea virus (BVDV). Infections with BVDV cause substantial economic losses brought about by its effects on reproduction and exacerbation of concurrent bacterial or viral infections. Since this disease was first described in 1946, diagnostic tools and disease control strategies have evolved considerably. Within Europe, an increasing number of countries have been implementing successful systematic control programmes, highlighting the feasibility and benefits of BVDV control. With its focus on the Northern Ireland industry, this thesis aims to identify and address important knowledge gaps in relation to BVD control in order to implement a systematic disease control programme. Diagnostic tools were reviewed by comparing and validating reverse transcription polymerase chain reaction (RT-PCR) methods, evaluating the testing of serum pools for antibody and by comparing commercial enzyme-linked immunosorbent assay (ELlSA) kits. A non-random survey for antibodies and virus indicated widespread seropositivity to BVDV and bovine herpesvirus type 1 in bulk tank milk samples from 181 dairy herds based across the country. It was followed by a cross-sectional study of dairy and suckler herds, including a risk factor analysis, which looked for evidence of viral circulation in the young stock cohort. It found an overall true seroprevalence of 58.7% (95% Cl: [54.7-62.70/0]). Finally, a genetic typing study in bovine samples collected between 1999 and 2011 did not detect any evidence of BVDV-2 or border disease virus. The analysis indicated that the predominant subtype circulating in Northern Ireland is BVDV-1a and described for the first time the detection of BVDV-1b. Results obtained have been employed to inform decisions on the most appropriate BVD control programme for Northern Ireland, to generate data on available diagnostic investigation tools and to provide a benchmark to assess the success of such a programme.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available