Use this URL to cite or link to this record in EThOS: http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.692272
Title: Towards the total synthesis of (-)-euonyminol
Author: Wong, Yau Nga
Awarding Body: Imperial College London
Current Institution: Imperial College London
Date of Award: 2012
Availability of Full Text:
Access from EThOS:
Full text unavailable from EThOS. Please try the link below.
Access from Institution:
Abstract:
Since its isolation from the Celastraceae vine Tripterygium wilfordii Hook in 1953, (-)-euonyminol remains the most highly oxygenated dihydro-??-agarofuran core found in a variety of bioactive Celastraceae natural products, including hypoglaunine B and hyponine B, both of which had been identified as potential anti-HIV agents. This thesis contains an overview of the natural products of the Celastraceae family and the wide spectrum of interesting biological activity that they display, with particular focus upon anti-HIV properties. Prior synthetic work towards euonyminol and background synthetic studies towards the construction of related decalin scaffolds via ring closing metathesis are also described. The remainder of this thesis describes the efforts made towards the total synthesis of (-)-euonyminol via both a two-directional method and an alternative ring-opening-ring-closing metathesis approach, the viability of which was proven using model systems.
Supervisor: Spivey, Alan Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID: uk.bl.ethos.692272  DOI: Not available
Share: