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Title: Structural and kinetic characterisation of metallo-[beta]-lactamases from clinical and environmental sources
Author: Salimraj, Ramya
ISNI:       0000 0004 5917 3395
Awarding Body: University of Bristol
Current Institution: University of Bristol
Date of Award: 2015
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Production of metallo-[beta]-lactamase (MBL) proteins protects Gram-negative bacteria from almost all [beta]-lactam antibiotics. MBLs hydrolyse [beta]-lactams, abolishing their antimicrobial activity. One method of restoring [beta]-lactam efficacy against MBL producing organisms would be co-administration with an MBL inhibitor, but to date no such inhibitor is commercially available. This project sought to express and characterise a range of MBLs, with the aims of both understanding structure-function relationships within this enzyme family and aiding the identification of MBL inhibitors. VIM-1 is an MBL commonly identified in resistant clinical isolates.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available