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Title: Generating patient-derived induced pluripotent stem cells to model Parkinson's disease
Author: Barbuti, Peter Antony
ISNI:       0000 0004 5917 3344
Awarding Body: University of Bristol
Current Institution: University of Bristol
Date of Award: 2014
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Parkinson's disease (PD) is a chronic progressive neurodegenerative disease of which there is no cure. PD occurs due to the selective degeneration of A9 midbrain dopaminergic neurons (mDANs) of the substantia nigra pars compacta (SNc) of the midbrain. Stem cells have the ability to generate any cell in the body, including the A9 mDANs of the SNc that are selectively degenerated in PD. However, in order to improve treatment for PD, these mDANs of the SNc need to be successfully recapitulated in-vitro, and is thus the central dogma of this research.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available