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Title: Defining spatiotemporal patterns regulating T cell function in peripheral tolerance induction
Author: Tunbridge, Helen
ISNI:       0000 0004 5916 8393
Awarding Body: University of Bristol
Current Institution: University of Bristol
Date of Award: 2016
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In the Tg4 murine model of multiple sclerosis, experimental autoimmune encephalomyelitis, disease burden can be reduced by repeated doses of self-peptide, resulting in the conversion of pathogenic T H1 cells into tolerant IL-10-secreting regulatory cells. This work sought to identify whether there are any differences in the spatiotemporal organisation of signalling intermediates in these two cell types using live cell imaging of T cells transduced with GFP-tagged signalling intermediates. Pattern classification of distributions found at the T:B cell interface was used to identify any altered localisation. The distribution of all sensors tested have already been established in a model of foreign antigen (5C.C7 transgenic mouse) and the function of these interface structures inferred from the roles of proteins that congregate there. Thus we can relate structure to function and better understand the effects of altered localisation of proteins in tolerance.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available