Use this URL to cite or link to this record in EThOS:
Title: Causes and consequences of cardiovascular health variation across the lifecourse
Author: Wade, Kaitlin Hazel
ISNI:       0000 0004 5915 9737
Awarding Body: University of Bristol
Current Institution: University of Bristol
Date of Award: 2015
Availability of Full Text:
Access from EThOS:
Cardiovascular diseases (CVDs) are the leading cause of worldwide mortality. Epidemiological studies have provided evidence for relationships between an adverse cardiovascular profile throughout the lifecourse and mortality from all causes, CVDs, diabetes and many cancers. Furthermore, cardiovascular health can be altered by both genetic and environmental factors at different stages of the lifecourse, where early life may be of particular importance for reducing the risk of adverse cardiovascular outcomes in later life. Within this thesis, I aimed to characterise cardiovascular health as a complex phenotype, distinguishing between BP (often measured within large cohort studies) and more detailed measures of peripheral and central vascular function and structure, with the aim of determining if BP is a good proxy for overall cardiovascular health. I aimed to assess the associations of genetic variation and selected environmental factors throughout childhood and adolescence (specifically parental lifestyle, feeding behaviour, dietary components, cardiometabolic traits and adiposity) with later cardiovascular health. I used a variety of resources and methods to improve causal inference including large-scale prospective study designs in the Avon Longitudinal Study of Parents and Children (ALSPAC) and the Promotion of Breast feeding Intervention Trial (PRO BIT) based in Belarus and Mendelian randomisation (MR), a method utilising genetic variation to overcome limitations in observational studies, such as confounding, bias and reverse causation.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available