Use this URL to cite or link to this record in EThOS: http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.690758
Title: Novel strategies for the site-selective C-H functionalisation of arenes
Author: Montgomery, Michelle
ISNI:       0000 0004 5915 3028
Awarding Body: University of Bristol
Current Institution: University of Bristol
Date of Award: 2015
Availability of Full Text:
Access through EThOS:
Abstract:
Substituted arenes are ubiquitous frameworks within the pharmaceutical, agrochemical and materials science industry. These valuable motifs have traditionally been prepared by electrophilic or radical substitution reactions, e.g. Friedel-Crafts acylation, however, their synthesis has been revolutionised through the development of transition metal catalysed C-H functionalisatipn reactions. The palladium-catalysed direct arylation of estrone has been achieved using a carbamate directing group to create a modest library of 2-aryl-3-diethylcarbamate estrones. Cleavage of the carbamate directing group with lithium aluminium hydride affords the corresponding 2- arylestradiol.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID: uk.bl.ethos.690758  DOI: Not available
Share: