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Title: Investigating the trafficking and associations of CD47 during erythropoiesis
Author: Mordue, Kathryn Elizabeth
ISNI:       0000 0004 5917 2421
Awarding Body: University of Bristol
Current Institution: University of Bristol
Date of Award: 2015
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The 'marker of self' protein C047 is an unusual component of the band 3 macrocomplex because it is already expressed on the erythroblast prior to band 3 and protein 4.2 expression, upon which C047 is dependent for its membrane stability. We hypothesised that either an alternative C047 isoform is initially expressed before switching to the erythroid C047 isoform 2, or that C047 isoform 2 is expressed throughout terminal differentiation and is dependent upon an alternative interaction to maintain its membrane stability before incorporation into the band 3 macrocomplex. The work presented in this thesis showed that C047 isoform 2 and C047 isoforms 3 and 4, were expressed during terminal differentiation. However, unlike isoform 2, C047 isoforms 3 and 4 were not detected at the erythroblast membrane, indicating that C047 does not undergo isoform switching.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available