Use this URL to cite or link to this record in EThOS:
Title: Characterization of extracellular signal-regulated Kinase1/2 (ERK1/2) signalling pathway at the μ-opioid receptor (MOPr)
Author: Tsisanova, Elena
ISNI:       0000 0004 5916 7745
Awarding Body: University of Bristol
Current Institution: University of Bristol
Date of Award: 2015
Availability of Full Text:
Access from EThOS:
Opioid drugs and their receptors are one of the most extensively studied areas of pharmacology, and in relation to biased agonism in particular. Previous research indicated that biased agonist at the Il-opioid receptor (MOPr) can be detected. Biased agonism theory, when applied to MOPr, offers the possibility to synthesize opioid ligands, lacking such lifethreatening side effects as addiction, tolerance, hyperalgesia and respiratory depression. In the current project the ability of MOPr ligands to activate Extracellular signal-Regulated Kinases 1/2 (ERKl/2), a key mediator of GPCR actions in cells, was studied. The MOPr ligands (DAMGO, morphine, buprenorphine, methadone, oxycodone, etorphine, pentazocine and endomorphin-2) were used that display different degrees of bias between G-protein and arrestin pathways as well as different efficacies for G protein activation. The model system used was HEK293 cells stably expressing MOPr.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available