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Title: Systemic microvascular dysfunction in acute albuminuria
Author: Betteridge, Kai Brodie
ISNI:       0000 0004 5914 5693
Awarding Body: University of Bristol
Current Institution: University of Bristol
Date of Award: 2014
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Patients with albuminuria have widespread endothelial dysfunction and increased microvascular permeability however the underlying mechanism remains unclear. The endothelial glycocalyx coats the luminal surface of all blood vessels, is a key regulator of permeability, and recent reports suggest that its widespread disruption provides the potential mechanistic link between these pathologies. To test this hypothesis I designed and validated a combined confocal-fluorescent imaging method for assessing structural-functional relationships between glycocalyx and albumin flux (PsBSA) in systemic mesenteric microvessels of rats with and without acute albuminuria in vivo. To validate my technique I modulated the glycocalyx in real time using neuraminidase and compared in vivo structural-functional assessments directly to structural assessments observed in the same vessels subsequently preserved for high resolution electron microscopic analysis.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available