Use this URL to cite or link to this record in EThOS:
Title: Influence of age, exercise and atrial fibrillation on the cerebrovascular function
Author: Dutra Braz, Igor
ISNI:       0000 0004 5924 2194
Awarding Body: University of Birmingham
Current Institution: University of Birmingham
Date of Award: 2016
Availability of Full Text:
Access from EThOS:
Access from Institution:
Ageing is associated with morphologic and functional changes in the brain, and is a major risk factor for cerebral vascular disease and dementia. Exercise is well known to promote cardiovascular health and reduce the age-related cognitive decline, but the mechanisms underlying this protective effect are not fully understood. Cardiovascular diseases, such as atrial fibrillation (AF), can exacerbate the risk of brain disease. This thesis aimed to assess the influence of ageing, exercise and AF on the cerebral blood flow and its regulation. It was observed that a difference of ≈55% in daily physical activity levels in a cohort of healthy old individuals did not influence internal carotid and vertebral artery blood flow. However, a high cardiorespiratory fitness was associated with increased bilateral internal carotid artery blood flow in young and old individuals when compared to their sedentary counterparts, but the influence on cerebral vasodilatory reserve is still unclear. AF patients had lower cerebral vasodilatory reserve, but preserved dynamic cerebral autoregulation, when compared to healthy controls. Future research is needed to elucidate whether cerebral haemodynamics is modified by exercise training in AF patients.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available
Keywords: QH301 Biology ; QR Microbiology ; RC Internal medicine