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Title: Clinical symptoms, social and role functioning, longer-term cortisol levels, and brain activation during working memory and rest in the early stages of mental health problems
Author: Heinze, Kareen
ISNI:       0000 0004 5923 9817
Awarding Body: University of Birmingham
Current Institution: University of Birmingham
Date of Award: 2016
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Mental disorders are associated with a range of neurobiological abnormalities, including hormonal disturbances and brain changes. This thesis looked at the early stages of mental disorders in general, and specifically at the ultra-high risk state for psychosis. 73 help-seeking youths aged 16-26 years were interviewed for clinical symptomatology and functioning, and followed up after 3 and 6 months. Neurobiological assessments were additionally undertaken in a subset of those clinical participants (n = 35), and healthy controls (HC, n = 35), involving hair cortisol analyses, and brain imaging during working memory processes and rest. Significantly increased hair cortisol levels, and brain hypo-activation during working memory processes and subtly decreased resting-state brain connectivity were discovered in clinical participants as compared to HC. Early mental health problems appear to have some neurobiological manifestations, however, larger cohort studies with multiple follow-up assessments over an extended time period are needed to replicate findings and to draw firm conclusions addressing clinical practice.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available
Keywords: BF Psychology